Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2013 Sep;17(5):922-3.
doi: 10.4103/2230-8210.117220.

Acute mania after thyroxin supplementation in hypothyroid state

Rohit Verma  1 , Ankur Sachdeva, Yogendra Singh, Yatan P S Balhara
Affiliations
Case Reports

Acute mania after thyroxin supplementation in hypothyroid state

Rohit Verma et al. Indian J Endocrinol Metab. 2013 Sep.

Abstract

The current literature variedly ascribes depressive and manic symptoms to hypo- and hyperthyroid state, respectively, reporting mania in hypothyroidism as an unusual entity. More unusual is precipitation of manic state in hypothyroid subjects after thyroxine supplementation for which studies report otherwise treating manic symptoms in hypothyroid state with thyroxine. We report a case of a patient whose acute mania appears to have been precipitated by thyroxine supplementation in hypothyroidism state. This case underscores the importance of thyroid screening in patients with mood and psychotic disorders, as well as the potency of thyroxine in producing manic symptoms.

Keywords: Hypothroidism; mania; thyroxine supplementation.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared

References

    1. Whybrow PC, Bauer M. Behavioral and psychiatric aspects in hypothyroidism. In: Braverman LE, Utiger RD, editors. Werner & Ingbar's The Thyroid: A Fundamental and Clinical Text. Philadelphia: Lippincott Williams & Wilkins; 2005. pp. 842–50.
    1. Chakrabarti S. Thyroid functions and bipolar affective disorder. J Thyroid Res. 2011 2011:306367. - PMC - PubMed
    1. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: Reliability, validity and sensitivity. Br J Psychiatry. 1978;133:429–35. - PubMed
    1. Balldin J, Berggren U, Rybo E, Kjellbo H, Lindstedt G. Treatment resistant mania with primary hypothyroidism: A case of recovery after levothyroxine. J Clin Psychiatry. 1987;48:490–1. - PubMed
    1. Khemka D, Ali JA, Koch CA. Primary hypothyroidism associated with acute mania: Case series and literature review. Exp Clin Endocrinol Diabetes. 2011;119:513–7. - PubMed

Publication types