Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Oct 1:11:246.
doi: 10.1186/1477-7819-11-246.

Characteristic analysis of α-fetoprotein-producing gastric carcinoma in China

Xiao-Dong Li  1 , Chang-Ping Wu, Mei Ji, Jun Wu, Binfeng Lu, Hong-Bing Shi, Jing-Ting Jiang
Affiliations
Review

Characteristic analysis of α-fetoprotein-producing gastric carcinoma in China

Xiao-Dong Li et al. World J Surg Oncol. .

Abstract

α-Fetoprotein-producing gastric cancer (AFPGC) is a rare type of gastric cancer. The largest population of patients with AFPGC is found in China. In the present study, a total of 4,779 GC patients, including 317 AFPGC patients, from 11 clinical studies in China with a general AFPGC/GC ratio of 6.63% were summarized and analyzed. On the basis of analysis of the clinical data, the patients with AFPGC had larger tumor size, weaker cell differentiation, worse histopathological types, deeper serosal infiltration, more lymph node and liver metastases, poorer stages, shorter survival time and more positive expression of vascular endothelial growth factors than the patients without AFPGC. Our observation is consistent with previous results reported in studies of AFPGC. Overall, AFPGC is a subtype of GC with a poor prognosis.

PubMed Disclaimer

References

    1. Bergstrand CG, Czar B. Demonstration of a new protein fraction in serum from the human fetus. Scand J Clin Lab Invest. 1956;8:174. doi: 10.3109/00365515609049266. - DOI - PubMed
    1. Adachi Y, Tsuchihashi J, Shiraishi N, Yasuda K, Etoh T, Kitano S. AFP-producing gastric carcinoma: multivariate analysis of prognostic factors in 270 patients. Oncology. 2003;65:95–101. doi: 10.1159/000072332. - DOI - PubMed
    1. Bourreille J, Metayer P, Sauger F, Matray F, Fondimare A. [Existence of α-fetoprotein during gastric-origin secondary cancer of the liver] [in French] Presse Med. 1970;78:1277–1278. - PubMed
    1. Shibata Y, Sato K, Kodama M, Nanjyo H. α-fetoprotein-producing early gastric cancer of the remnant stomach: report of a case. Surg Today. 2007;37:995–999. doi: 10.1007/s00595-007-3501-0. - DOI - PubMed
    1. Alpert E, Pinn VW, Isselbacher KJ. α-Fetoprotein in a patient with gastric carcinoma metastatic to the liver. N Engl J Med. 1971;285:1058–1059. doi: 10.1056/NEJM197111042851905. - DOI - PubMed

Publication types