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. 2013 Oct 1;3(1):21.
doi: 10.1186/2045-9912-3-21.

Cold Atmospheric Plasma: methods of production and application in dentistry and oncology

Clotilde Hoffmann  1 , Carlos Berganza, John Zhang
Affiliations

Cold Atmospheric Plasma: methods of production and application in dentistry and oncology

Clotilde Hoffmann et al. Med Gas Res. .

Abstract

Cold Atmospheric Plasma is an ionized gas that has recently been extensively studied by researchers as a possible therapy in dentistry and oncology. Several different gases can be used to produce Cold Atmospheric Plasma such as Helium, Argon, Nitrogen, Heliox, and air. There are many methods of production by which cold atmospheric plasma is created. Each unique method can be used in different biomedical areas. In dentistry, researchers have mostly investigated the antimicrobial effects produced by plasma as a means to remove dental biofilms and eradicate oral pathogens. It has been shown that reactive oxidative species, charged particles, and UV photons play the main role. Cold Atmospheric Plasma has also found a minor, but important role in tooth whitening and composite restoration. Furthermore, it has been demonstrated that Cold Atmospheric Plasma induces apoptosis, necrosis, cell detachment, and senescence by disrupting the S phase of cell replication in tumor cells. This unique finding opens up its potential therapy in oncology.

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Figures

Figure 1
Figure 1
The four states of matter.
Figure 2
Figure 2
.Diagram of a Dielectric Barrier Discharge and a Floating Electrode Dielectric Barrier Discharge. A presents the formation of Plasma by the Dielectric Barrier Discharge (DBD) and B presents the Floating Electrode Dielectric Barrier Discharge (FE-DBD).
Figure 3
Figure 3
.Diagram of a Atmospheric Pressure Plasma Jet and a Plasma Needle. A presents a schematic of the APPJ created by Schütze et al in 1992 and B presents a schematic of the plasma needle created by Stoffels et al in 2004.
Figure 4
Figure 4
A schematic of the plasma pencil created by Laroussi et al.
Figure 5
Figure 5
The different components of a tooth[153].
See this image and copyright information in PMC

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