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. 2013 Oct;15(10):1135-6.
doi: 10.1038/ncb2849.

TSC on the peroxisome controls mTORC1

Don Benjamin  1 , Michael N Hall
Affiliations

TSC on the peroxisome controls mTORC1

Don Benjamin et al. Nat Cell Biol. 2013 Oct.

Abstract

mTOR is a central controller that integrates many inputs to regulate cell growth and ensure cellular homeostasis. The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species. Thus, mTOR may avoid confounding different inputs by sensing them at different cellular locations.

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References

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