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Review
. 2013 Oct 1;5(10):a011197.
doi: 10.1101/cshperspect.a011197.

Signaling by the TGFβ superfamily

Jeffrey L Wrana  1
Affiliations
Review

Signaling by the TGFβ superfamily

Jeffrey L Wrana. Cold Spring Harb Perspect Biol. .

Abstract

TGF-β superfamily members (e.g., activins and BMPs) regulate diverse developmental and physiological processes. Their signals are conveyed through transmembrane serine/threonine kinase receptors to intracellular mediators (mainly Smads).

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Figures

Figure 1.
Figure 1.
Smad signaling.
Figure 2.
Figure 2.
Non-Smad signals.
See this image and copyright information in PMC

References

    1. Attisano L, Wrana JL 2002. Signal transduction by the TGF-β superfamily. Science 296: 1646–1647 - PubMed
    1. Attisano L, Wrana JL 2013. Signal integration in TGF-β, WNT and Hippo pathways. F1000Prime Rep 5: 17. - PMC - PubMed
    1. Green JB, Smith JC 1990. Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate. Nature 347: 391–394 - PubMed
    1. Griswold-Prenner I, Kamibayashi C, Maruoka EM, Mumby MC, Derynck R 1998. Physical and functional interactions between type I transforming growth factor β receptors and Bα, a WD-40 repeat subunit of phosphatase 2A. Mol Cell Biol 18: 6595–6604 - PMC - PubMed
    1. Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R 2007. TGF-β activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J 26: 3957–3967 - PMC - PubMed

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