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Review
. 2013 Oct 1;3(10):a014324.
doi: 10.1101/cshperspect.a014324.

Myc function in Drosophila

Peter Gallant  1
Affiliations
Review

Myc function in Drosophila

Peter Gallant. Cold Spring Harb Perspect Med. .

Abstract

Drosophila contains a single MYC gene. Like its vertebrate homologs, it encodes a transcription factor that activates many targets, including prominently genes involved in ribosome biogenesis and translation. This activity makes Myc a central regulator of growth and/or proliferation of many cell types, such as imaginal disc cells, polyploid cells, stem cells, and blood cells. Importantly, not only does Myc act cell autonomously but it also affects the fate of adjacent cells and tissues. This potential of Myc is harnessed by many different signaling pathways, involving, among others, Wg, Dpp, Hpo, ecdysone, insulin, and mTOR.

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Figures

Figure 1.
Figure 1.
dMyc controls ribosome biogenesis and protein synthesis, and as a consequence, the accumulation of cellular mass and animal growth. Depending on tissue type, dMyc’s activity primarily affects cell number, cell size, or cell fate. See text for details.
See this image and copyright information in PMC

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