Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Aug;7(8):1596-8.
doi: 10.7860/JCDR/2013/6162.3234. Epub 2013 Aug 1.

A comparative study of lipid profile and oestradiol in pre- and post-menopausal women

Srinivas Reddy Kilim  1 , Srinivasa Rao Chandala
Affiliations

A comparative study of lipid profile and oestradiol in pre- and post-menopausal women

Srinivas Reddy Kilim et al. J Clin Diagn Res. 2013 Aug.

Abstract

Objectives: To investigate the relationship between the menopausal status and related hormonal variation of oestradiol with plasma lipid concentrations.

Material and methods: Fifty premenopausal women and fifty postmenopausal women subjects were selected. Data was collected through clinical evaluation from questionnaires and laboratory investigations. Plasma oestradiol and lipid profile determinations were done by using competitive binding immunoassay methods and enzymatic methods respectively. Student's T test and Pearson's test of correlation were used for the statistical analysis. P-values of < 0.05 were considered to be statistically significant.

Results: There was a significant increase in serum Total Cholesterol (TC), Triglycerides (TG), LDL-cholesterol and VLDL-cholesterol levels in post-menopausal women. HDL-cholesterol level was significantly decreased in post-menopausal women. The calculated atherogenic index (Total Cholesterol/HDL ratio) was significantly increased in post-menopausal women as compared to that in premenopausal women. Oestradiol concentration was significantly lower (p<0.001) in post-menopausal women.

Discussion: Oestrogen changes the vascular permeability by increasing nitrous oxide production. It maintains a healthy lipoprotein profile. It stabilizes the endothelial cells, enhances antioxidant effect and alters fibrinolysis protein. All these cardioprotective mechanisms are lost in menopause. Postmenopausal women develop an increased risk for cardiovascular disease.

Conclusion: Menopause leads to changes in lipid profile by reducing HDL, and elevating Total Cholesterol (TC), triglycerides (TG), LDL-cholesterol and VLDL-cholesterol, thus increasing the risk for cardiovascular disease. These changes are caused by reduced oestrogen concentrations which are seen in menopause.

Keywords: Cardiovascular disease; Coronary heart disease; Menopause; Oestrogen; Plasma lipids.

PubMed Disclaimer

Figures

[Table/Fig-2]:
[Table/Fig-2]:
Comparision of lipid profile in pre and post menopausal women
[Table/Fig-4]:
[Table/Fig-4]:
Correlation between LDL concentration and Estradiol in post menopausal women
[Table/Fig-5]:
[Table/Fig-5]:
Correlation between HDL concentration and Estradiol in post menopausal women
See this image and copyright information in PMC

References

    1. Couderc R, Machi M. Lipoprotein(a): risk factor for atherosclerotic vascular disease important to take into account inpractice. Ann-Biol-Clin. 1999;57(2):157–67. - PubMed
    1. Rich-Edward JW, Manson JE, Hennokeni CH. The Primary prevention of coronary heart disease in women. N. Engl. J Med. 1995;332(20):1758–66. - PubMed
    1. Lerner DJ, Kannel WB. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26 year follow-up of the Framingham population. Am Heart J. 1986;383 - PubMed
    1. Laufer Larry R, Gambone-Climacteric Joseph C, Hacker, et al., editors. Essentials of Obstetrics and Gynecology. 4 th edition. Elsevier Saunders;
    1. Shifren Jan L, Schiff Isaac. Berek and Novak’s Gynecology. 14th Edition. Lippincott Williams and Wilkins; 2007. Section VII - Reproductive Endocrinology 32 – Menopause, Editors: Berek, Jonathan S.Title.

LinkOut - more resources