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. 2013 Nov 21;11(43):7451-4.
doi: 10.1039/c3ob41621f.

A facile copper(I)-catalyzed homocoupling of terminal alkynes to 1,3-diynes with diaziridinone under mild conditions

Yingguang Zhu  1 , Yian Shi
Affiliations

A facile copper(I)-catalyzed homocoupling of terminal alkynes to 1,3-diynes with diaziridinone under mild conditions

Yingguang Zhu et al. Org Biomol Chem. .

Abstract

A novel and efficient Cu(I)-catalyzed oxidative homocoupling of terminal alkynes with diaziridinone as an oxidant is described. Various terminal alkynes can be transformed into the corresponding 1,3-diynes in good yields. The reaction process is base-free, operationally simple, and amenable to the gram scale.

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Figures

Scheme 1
Scheme 1
Cu(I)-catalyzed oxidative homocoupling of 2.
Scheme 2
Scheme 2
Proposed catalytic cycle for the oxidative homocoupling.
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