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. 2014 Jul;27(11):1169-71.
doi: 10.3109/14767058.2013.850483. Epub 2013 Oct 22.

The impact of loop electrosurgical excision procedure (LEEP) for CIN 2,3 on spontaneous preterm delivery in twin pregnancies by assisted reproductive technique: preliminary data

Andrea Ciavattini  1 , Piergiorgio Stortoni, Francesca Mancioli, Danila Puglia, Andrea Luigi Tranquilli, Carlo Antonio Liverani
Affiliations

The impact of loop electrosurgical excision procedure (LEEP) for CIN 2,3 on spontaneous preterm delivery in twin pregnancies by assisted reproductive technique: preliminary data

Andrea Ciavattini et al. J Matern Fetal Neonatal Med. 2014 Jul.

Abstract

The objective of this study was to compare the frequency of spontaneous preterm delivery before 35 weeks in 7 dichorionic twin pregnancies obtained after loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia (CIN) 2,3 with respect to 21 twin pregnancies without previous cervical treatment. All the pregnancies were obtained after assisted reproduction techniques (ART). Same age at delivery was observed between two groups (p = 0.81) and none of our twin pregnancies after LEEP had a threatened preterm labor while four controls (19%) underwent a spontaneous preterm delivery (p = 0.35). These preliminary data seem to indicate that LEEP may not be responsible of spontaneous preterm delivery in twin pregnancies subsequent to ART.

Keywords: Assisted reproduction techniques; cervical treatment; loop electrosurgical excision procedure; preterm delivery; twin pregnancies.

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