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Comment
. 2013 Nov 1;12(21):3355-6.
doi: 10.4161/cc.26637. Epub 2013 Sep 27.

TRPC1: getting physical in space

Indu S Ambudkar  1
Affiliations
Comment

TRPC1: getting physical in space

Indu S Ambudkar. Cell Cycle. .
No abstract available

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Figures

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Figure 1. Functional link between TRPC1, Ca2+ signaling mechanisms, and cell cycle progression in skeletal muscle cells. Normal gravity or mechanical forces stimulate TRPC1 activation and promote Ca2+ signaling, leading to cyclin B degradation, a signal for progression of cell cycle from G2/M to G1 phase. This results in myogenesis. In contrast, microgravity conditions lead to loss of TRPC1 function as a result of decreased expression of the channel and, consequently, result in attenuation of cell cycle progression, possibly leading to atrophy of muscle tissue with prolonged stress. Abbreviations: TRPC1, transient receptor potential canonical 1; NFAT, nuclear factor of activated T-cells; IGF, insulin like growth factor; CaM, calmodulin; CaMKll, calmodulin-dependent kinase ll.
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