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Case Reports
. 2014 Feb;99(1):28-36.
doi: 10.1136/archdischild-2012-302404. Epub 2013 Oct 3.

Fitting and flailing: recognition of paediatric antiphospholipid syndrome

H Freeman  1 , J Patel, D Fernandez, P Sharples, A V Ramanan
Affiliations
Case Reports

Fitting and flailing: recognition of paediatric antiphospholipid syndrome

H Freeman et al. Arch Dis Child Educ Pract Ed. 2014 Feb.

Erratum in

  • Arch Dis Child Educ Pract Ed. 2014 Apr;99(2):80

Abstract

Antiphospholipid syndrome (APS) is a systemic autoimmune condition where the presence of antiphospholipid antibodies is thought to predispose to thrombotic events. It is uncommon in the paediatric population, but current diagnostic criteria are based on adult population studies, making assessment of its true paediatric prevalence difficult. We present two cases of paediatric APS, who presented with primary neurological events, and discuss approaches to diagnosis, interpretation of screening investigations, including antinuclear antibodies (ANA), anti-extractable nuclear antigen (ENA) antibodies and lupus anticoagulant. Possible approaches to the management of paediatric APS are discussed.

Keywords: Neurology; Rheumatology.

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