Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Mar;45(1):48-53.
doi: 10.1007/s12029-013-9550-2.

Prognostic value of tumor-infiltrating mast cells in outcome of patients with esophagus squamous cell carcinoma

Ashraf Fakhrjou  1 , Seid Mahdi Niroumand-Oscoei, Mohamad Hosein Somi, Morteza Ghojazadeh, Shahnaz Naghashi, Shabnam Samankan
Affiliations

Prognostic value of tumor-infiltrating mast cells in outcome of patients with esophagus squamous cell carcinoma

Ashraf Fakhrjou et al. J Gastrointest Cancer. 2014 Mar.

Abstract

Background: Squamous cell carcinoma (SCC) of the esophagus is one of the most common malignancies of the gastrointestinal tract and carries poor prognosis. The role of mast cell density (MCD) in the prognosis of most human tumors is partly known, and there is a growing body of studies addressing it. However, the prognostic value of MCD has not been investigated in esophageal SCC, and thus, it was the subject during this study.

Methods: In this study, 78 patients with esophageal SCC in pT = 3 were selected, their MCD was evaluated with toluidine blue staining, and the relationship with survival rate was analyzed. Patients were compared in identical groups of lymph node involvement and post-surgery complementary therapy.

Results: Survival rate was significantly decreased in patients with high MCD based on Kaplan-Meier analysis (P < 0.001). This relationship was also found in groups with similar lymph node involvement and post-surgery therapies.

Conclusions: The results of the current study showed that high MCD in the invasive edge of tumor is related to tumor progression and decreased survival rate following surgery.

PubMed Disclaimer

References

    1. Hum Mol Genet. 2006 Aug 15;15(16):2421-37 - PubMed
    1. Int J Cancer. 2003 May 20;105(1):98-100 - PubMed
    1. Acta Histochem. 2010 May;112(3):233-9 - PubMed
    1. Genes Dev. 1999 Jun 1;13(11):1382-97 - PubMed
    1. Int J Biochem Cell Biol. 2010 May;42(5):551-4 - PubMed

Publication types

MeSH terms

LinkOut - more resources