doi: 10.1111/j.2042-7158.1978.tb13172.x.
Studies on the role of ACTH and of 5-HT in anxiety, using an animal model
- PMID: 24093
- DOI: 10.1111/j.2042-7158.1978.tb13172.x
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Studies on the role of ACTH and of 5-HT in anxiety, using an animal model
J Pharm Pharmacol.
1978 Feb.
Abstract
The effects of ACTH (5 & 7.5 microgram/100 g) were studied using a new animal model of anxiety. ACTH had an anxiogenic effect that was maximal during a 10 min test period starting 3 min after injection. The behavioural effects of ACTH were counteracted by chronic administration of chlordiazepoxide (5 mg kg-1 for 5 days) and by acute administration of ethanol (0.4 g kl-1). These anxiolytic drugs decreased the turnover of 5-HT in the midbrain, hypothalamus and cerebral cortex, whereas ACTH increased 5-HT turnover in the midbrain and hypothalamus. Is it therefore proposed that anxiety results from the action of ACTH, possibly on 5-HT pathways in the midbrain and hypothalamus.
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