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. 2014 Feb;33(1):16-22.
doi: 10.3109/15513815.2013.842270. Epub 2013 Oct 7.

Proportionate reduction in uncertainty of late onset infection in pre-term infants by neutrophil CD64 measurement

Janet Elizabeth Berrington  1 , Richard Iain Hearn, Chris Hall, Christopher James Stewart, Stephen Paul Cummings, Nicholas David Embleton
Affiliations

Proportionate reduction in uncertainty of late onset infection in pre-term infants by neutrophil CD64 measurement

Janet Elizabeth Berrington et al. Fetal Pediatr Pathol. 2014 Feb.

Abstract

Objective: Establish how neutrophil CD64 performs as a marker of definite infection in pre-term infants in comparison to C reactive protein (CRP) and procalcitonin (PCT).

Methods: A total of 38 pre-term infants with suspected late onset infection had CD64 measured by flow cytometry. Proportionate reduction in uncertainty (PRU) curves were generated for CD64 counts at various threshold values.

Results: PRU curves reduced the residual uncertainty of the presence of infection by up to 64%.

Conclusions: The CD64 appears to be a useful point of care test (POCT) for further defining the likelihood of infection and performs better than CRP or PCT at helping to rule in infection.

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