Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Nov;29(4):873-93.
doi: 10.1016/j.cger.2013.07.009.

Risk factors for the progression of mild cognitive impairment to dementia

Noll L Campbell  1 , Fred Unverzagt, Michael A LaMantia, Babar A Khan, Malaz A Boustani
Affiliations
Review

Risk factors for the progression of mild cognitive impairment to dementia

Noll L Campbell et al. Clin Geriatr Med. 2013 Nov.

Abstract

The increasing prevalence of cognitive impairment among the older adult population warrants attention to the identification of practices that may minimize the progression of early forms of cognitive impairment, including the transitional stage of mild cognitive impairment (MCI), to permanent stages of dementia. This article identifies both markers of disease progress and risk factors linked to the progression of MCI to dementia. Potentially modifiable risk factors may offer researchers a point of intervention to modify the effect of the risk factor and to minimize the future burden of dementia.

Keywords: Biomarkers; Dementia; Genetics; Mild cognitive impairment; Risk factors.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest for this article.

Figures

Fig. 1
Fig. 1
Risk factors for progression of MCI to normal cognition, vascular or mixed dementia, or Alzheimer-type dementia. APOE, apolipoprotein; CDR-sob, Clinical Dementia Rating scale sum of boxes; CLU, clusterin; HIS, Hachinski Ischemic Score; MMSE, Mini-Mental Status Examination; MCI, mild cognitive impairment; MTL, medial temporal lobe; t-Tau, total Tau protein from cerebrospinal fluid; WML, white matter lesions.
See this image and copyright information in PMC

References

    1. Ganguli M, Petersen RC. Mild cognitive impairment: challenging issues. Am J Geriatr Psychiatry. 2008;16(5):339–42. - PubMed
    1. Winblad B, Palmer K, Kivipelto M, et al. Mild cognitive impairment—beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med. 2004;256(3):240–6. - PubMed
    1. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004;256(3):183–94. - PubMed
    1. Petersen RC, Smith GE, Waring SC, et al. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56(3):303–8. - PubMed
    1. Petersen RC, Smith GE, Ivnik RJ, et al. Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals. JAMA. 1995;273(16):1274–8. - PubMed

Publication types