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Comment
. 2013 Oct 3;13(4):379-81.
doi: 10.1016/j.stem.2013.09.012.

Removing reprogramming roadblocks: Mbd3 depletion allows deterministic iPSC generation

Justin Brumbaugh  1 , Konrad Hochedlinger
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Removing reprogramming roadblocks: Mbd3 depletion allows deterministic iPSC generation

Justin Brumbaugh et al. Cell Stem Cell. .
Free article

Abstract

Transcription factor-induced pluripotency is extremely inefficient and assumed to be stochastic. In a recent Nature publication, Rais et al. show that depletion of the methyl-binding protein 3 yields reprogramming efficiencies of up to 100% within days, suggesting that elimination of a single gene suffices to render reprogramming a deterministic process.

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  • Deterministic direct reprogramming of somatic cells to pluripotency.
    Rais Y, Zviran A, Geula S, Gafni O, Chomsky E, Viukov S, Mansour AA, Caspi I, Krupalnik V, Zerbib M, Maza I, Mor N, Baran D, Weinberger L, Jaitin DA, Lara-Astiaso D, Blecher-Gonen R, Shipony Z, Mukamel Z, Hagai T, Gilad S, Amann-Zalcenstein D, Tanay A, Amit I, Novershtern N, Hanna JH. Rais Y, et al. Nature. 2013 Oct 3;502(7469):65-70. doi: 10.1038/nature12587. Epub 2013 Sep 18. Nature. 2013. PMID: 24048479

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