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Review
. 2013:117:229-41.
doi: 10.1016/B978-0-444-53491-0.00019-5.

Multiple system atrophy

Gregor K Wenning  1 , Florian Krismer
Affiliations
Review

Multiple system atrophy

Gregor K Wenning et al. Handb Clin Neurol. 2013.

Abstract

Multiple system atrophy (MSA) is a sporadic and fatal α-synuclein-linked oligodendrogliopathy manifesting with progressive autonomic failure, poorly levodopa-responsive parkinsonism, and cerebellar ataxia, in any combination. Here we review key aspects of MSA integrating important insights from rapidly emerging fields such as genetics, diagnostic work-up including imaging, and translational therapies aimed at disease modification.

Keywords: Multiple system atrophy; autonomic failure; cerebellar ataxia; orthostatic hypotension; parkinsonism; therapy; urogenital failure.

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