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Meta-Analysis
. 2013 Oct 25;169(1):62-72.
doi: 10.1016/j.ijcard.2013.08.078. Epub 2013 Sep 8.

Association of inflammatory factors with occurrence and recurrence of atrial fibrillation: a meta-analysis

Na Wu  1 , Bin Xu, Ying Xiang, Long Wu, Yao Zhang, Xiangyu Ma, Shifei Tong, Maoqing Shu, Zhiyuan Song, Yafei Li, Li Zhong
Affiliations
Meta-Analysis

Association of inflammatory factors with occurrence and recurrence of atrial fibrillation: a meta-analysis

Na Wu et al. Int J Cardiol. .

Abstract

Background: The role of circulating inflammatory factors in atrial fibrillation (AF) occurrence and recurrence remains inconclusive.

Methods: We conducted a meta-analysis of observational studies evaluating the association of inflammatory factors with AF risk, postoperative AF (POAF) occurrence after coronary artery bypass grafting (CABG) surgery, and AF recurrence after electrical cardioversion (EC) or catheter ablation.

Results: Increased C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α were significantly associated with AF risk (standardized mean difference [SMD] [95% confidence interval (CI)]: 0.95 [0.72-1.18], 0.89 [0.64-1.15] and 2.20 [1.17-3.23], respectively). In subgroup analysis, CRP was significantly associated with persistent and permanent AF risk, but not with paroxysmal AF. Increased preoperative CRP and IL-6 were associated with greater risk of post-CABG AF (SMD [95% CI]: 0.28 [0.02-0.54] and 1.03 [0.03-2.04], respectively). Consistent significant associations between CRP and AF recurrence were found in both patient subgroups who underwent EC (SMD, 0.56; 95% CI, 0.36-0.76) and ablation (SMD, 0.48; 95% CI, 0.11-0.86). IL-6 was significantly associated with AF recurrence after ablation (SMD, 0.55; 95% CI, 0.25-0.85), but not with the recurrence after EC (SMD, 0.85; 95% CI, -0.26-1.95).

Conclusion: Increased circulating inflammatory factors, such as CRP and IL-6, are associated with greater AF risk in general population and patients who underwent CABG, as well as with AF recurrence after EC or ablation. Future research is warranted to elucidate the roles of other inflammatory markers, such as white blood cell, IL-8, and transforming growth factor-β1, in occurrence and recurrence of well-established different clinical subtypes of AF.

Keywords: Atrial fibrillation; Catheter ablation; Coronary artery bypass grafting surgery; Electrical cardioversion; Inflammatory factor; Meta-analysis.

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