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. 2014 Jan:184:327-34.
doi: 10.1016/j.envpol.2013.09.008. Epub 2013 Oct 1.

Serum biomarkers of polyfluoroalkyl compound exposure in young girls in Greater Cincinnati and the San Francisco Bay Area, USA

Susan M Pinney  1 , Frank M Biro, Gayle C Windham, Robert L Herrick, Lusine Yaghjyan, Antonia M Calafat, Paul Succop, Heidi Sucharew, Kathleen M Ball, Kayoko Kato, Lawrence H Kushi, Robert Bornschein
Affiliations

Serum biomarkers of polyfluoroalkyl compound exposure in young girls in Greater Cincinnati and the San Francisco Bay Area, USA

Susan M Pinney et al. Environ Pollut. 2014 Jan.

Abstract

PFC serum concentrations were measured in 6-8 year-old girls in Greater Cincinnati (GC) (N = 353) and the San Francisco Bay Area (SFBA) (N = 351). PFOA median concentration was lower in the SFBA than GC (5.8 vs. 7.3 ng/mL). In GC, 48/51 girls living in one area had PFOA concentrations above the NHANES 95th percentile for children 12-19 years (8.4 ng/mL), median 22.0 ng/mL. The duration of being breast fed was associated with higher serum PFOA at both sites and with higher PFOS, PFHxS and Me-PFOSA-AcOH concentrations in GC. Correlations of the PFC analytes with each other suggest that a source upriver from GC may have contributed to exposures through drinking water, and water treatment with granular activated carbon filtration resulted in less exposure for SWO girls compared to those in NKY. PFOA has been characterized as a drinking water contaminant, and water treatment systems effective in removing PFCs will reduce body burdens.

Keywords: Biomonitoring; Children; Drinking water contaminants; Human milk; Polyfluoroalkyl compounds (PFCs).

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Figures

Figure 1
Figure 1
Regression β Estimates for the Duration of Breastfeeding, by PFC and Site
See this image and copyright information in PMC

References

    1. Antignac JP, Veyrand B, Kadar H, Marchand P, Oleko A, Bizec BL, Vandentorren S. Occurrence of perfluorinated alkylated substances in breast milk of French women and relation with socio-demographical and clinical parameters: Results of the ELFE pilot study. Chemosphere. 2013;91:802–808. - PubMed
    1. Bartell SM, Calafat AM, Lyu C, Kato K, Ryan PB, Steenland K. Rate of decline in serum PFOA concentrations after granular activated carbon filtration at two public water systems in Ohio and West Virginia. Environ Health Perspect. 2010;118(2):222–228. - PMC - PubMed
    1. Begley TH, White K, Honigfort P, Twaroski ML, Neches R, Walker Perfluorochemicals: potential sources of and migration from food packaging. Food Addit Contam. 2005;22(10):1023–1031. - PubMed
    1. Calafat AM, Kuklenyik Z, Reidy JA, Caudill SP, Tully JS, Needham LL. Serum concentrations of 11 polyfluoroalkyl compounds in the US population: Data from the National Health and Nutrition Examination Survey (NHANES) Environ Sci Technol. 2007a;41(7):2237–2242. - PubMed
    1. Calafat AM, Wong L, Kuklenyik Z, Reidy JA, Needham LL. Polyfluoroalkyl chemicals in the US population: Data from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and comparisons with NHANES 1999–2000. Environ Health Perspect. 2007b;115(11):1596–1602. - PMC - PubMed

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