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. 1985 Aug;145(1):94-104.
doi: 10.1016/0042-6822(85)90204-1.

Sequences in the gag-pol-5'env region of avian leukosis viruses confer the ability to induce osteopetrosis

P R Shank, P J Schatz, L M Jensen, P N Tsichlis, J M Coffin, H L Robinson

Sequences in the gag-pol-5'env region of avian leukosis viruses confer the ability to induce osteopetrosis

P R Shank et al. Virology. 1985 Aug.

Abstract

DNA sequences encoding the genomes of three subgroup E avian leukosis viruses have been molecularly cloned. Virus recovered from one of these cloned DNAs (pRAV-0) caused no osteopetrosis while virus recovered from the second (lambda NY203) caused late onset osteopetrosis and virus recovered from the third (lambda NTRE-2) caused intermediate onset osteopetrosis. Restriction endonuclease fragments of the cloned viral DNAs were used to construct recombinant viruses that could be used to test for the role of gag-pol-5'env and 3'env-LTR sequences in the induction of osteopetrosis. The results of the pathogenicity tests indicate that gag-pol-5'env sequences confer the ability to induce osteopetrosis while 3'env-LTR sequences influence the time of onset and the severity of osteopetrosis.

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