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Comment
. 2013 Nov;20(11):1438-9.
doi: 10.1038/cdd.2013.111.

p53 talks to PARP: the increasing complexity of p53-induced cell death

K G Wiman  1
Affiliations
Comment

p53 talks to PARP: the increasing complexity of p53-induced cell death

K G Wiman. Cell Death Differ. 2013 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Loss of p53 function in tumors affects both apoptosis and necrosis. Left panel: Tumor cells carrying mutant p53 are deficient for both p53-dependent apoptosis and PARP-dependent necrosis in response to ROS-inducing stress, fueling tumor progression. Right panel: Restoration of wild-type p53 function should not only rescue p53-dependent apoptosis and senescence but also enhance PARP activity and rescue PARP-dependent necrosis, allowing efficient tumor eradication
See this image and copyright information in PMC

Comment on

  • p53 regulates a non-apoptotic death induced by ROS.
    Montero J, Dutta C, van Bodegom D, Weinstock D, Letai A. Montero J, et al. Cell Death Differ. 2013 Nov;20(11):1465-74. doi: 10.1038/cdd.2013.52. Epub 2013 May 24. Cell Death Differ. 2013. PMID: 23703322 Free PMC article.

References

    1. Vogelstein B, Lane D, Levine AJ. Nature. 2000. pp. 307–310. - PubMed
    1. Vousden KH, Prives C. Cell. 2009. pp. 413–431. - PubMed
    1. Halazonetis TD, Gorgoulis VG, Bartek J. Science. 2008. pp. 1352–1355. - PubMed
    1. Petitjean A, et al. Oncogene. 2007. pp. 2157–2165. - PubMed
    1. Soussi T, Wiman KG. Cancer Cell. 2007. pp. 303–312. - PubMed

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