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Comment
. 2014 Jan;11(1):5-7.
doi: 10.1038/cmi.2013.46. Epub 2013 Oct 7.

A fat story-antigen presentation by butyrophilin 3A1 to γδ T cells

Charlotte Esser
Comment

A fat story-antigen presentation by butyrophilin 3A1 to γδ T cells

Charlotte Esser. Cell Mol Immunol. 2014 Jan.
No abstract available

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Figures

Figure 1
Figure 1
(a) Prenyl derivatives are formed through different metabolic pathways in both eukaryotes and bacteria. The mevalonate pathway is upregulated by infection and cellular stress. Shown are two molecules known to stimulate γδ T cells. (b) IPP and HMBPP are presented in the shallow groove of cell-bound butyrophilin 3A1, and the complex is recognized by distinct γδ T-cell receptors, leading to their activation. HMBPP, (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate; IPP, isopentenyl pyrophosphate.
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References

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