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Comment
. 2013 Oct 30;32(21):2783-4.
doi: 10.1038/emboj.2013.225. Epub 2013 Oct 4.

The force and effect of cell proliferation

Pedro Campinho  1 , Carl-Philipp Heisenberg
Affiliations
Comment

The force and effect of cell proliferation

Pedro Campinho et al. EMBO J. .

Abstract

EMBO J 32: 2790–2803 doi:; DOI: 10.1038/emboj.2013.197; published online September 10 2013

The spatiotemporal control of cell divisions is a key factor in epithelial morphogenesis and patterning. Mao et al (2013) now describe how differential rates of proliferation within the Drosophila wing disc epithelium give rise to anisotropic tissue tension in peripheral/proximal regions of the disc. Such global tissue tension anisotropy in turn determines the orientation of cell divisions by controlling epithelial cell elongation.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Differential rates of cell division between distal (green) and proximal (red) regions of the Drosophila wing disc epithelium (1) give rise to global patterns of tension anisotropy within the tissue (2). This tension anisotropy promotes cell elongation along the main axis of tension, thereby controlling the orientation of cell division via cell shape anisotropies in proximal regions of the wing disc (3); D, distal; P, proximal.
See this image and copyright information in PMC

Comment on

References

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