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. 2013 Oct 2;8(10):e76492.
doi: 10.1371/journal.pone.0076492. eCollection 2013.

Enterovirus 74 infection in children

Matthew Peacey  1 , Richard J Hall, Jing Wang, Angela K Todd, Seiha Yen, Jasmine Chan-Hyams, Christy J Rand, Jo-Ann Stanton, Q Sue Huang
Affiliations

Enterovirus 74 infection in children

Matthew Peacey et al. PLoS One. .

Abstract

Enterovirus 74 (EV74) is a rarely detected viral infection of children. In 2010, EV74 was identified in New Zealand in a 2 year old child with acute flaccid paralysis (AFP) through routine polio AFP surveillance. A further three cases of EV74 were identified in children within six months. These cases are the first report of EV74 in New Zealand. In this study we describe the near complete genome sequence of four EV74 isolates from New Zealand, which shows only limited sequence identity in the non-structural proteins when compared to the other two known EV74 sequences. As is typical of enteroviruses multiple recombination events were evident, particularly in the P2 region and P3 regions. This is the first complete EV74 genome sequenced from a patient with acute flaccid paralysis.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Similarity plot comparing NZ2284 with all available prototype EV B strains and PV1.
Schematic above the graph indicates the position of each gene within the EV genome.
Figure 2
Figure 2. Phylogenetic trees for each region of all available prototype EV B strains.
Trees were rooted with PV1. Bootstrap values below 50 were removed. Bars indicate nucleotide substitution distance.
Figure 3
Figure 3. Phylogenetic trees for each genome fragment of all available prototype EV B strains.
Trees were rooted with PV1. Bootstrap values below 50 were removed. Bars indicate nucleotide substitution distance.
Figure 4
Figure 4. Bootscan analysis of NZ2284 and EV B strains.
A, comparison of NZ2284 with all available prototype EV B strains. B, comparison of NZ2284 with all available prototype EV B strains excluding strains E1, E9, EV84 and EV101 but with a consensus sequence of these 4 strains. C, comparison of NZ2284 with all available prototype EV B strains including E12 but excluding strains E1, E9, EV84 and EV101. Schematic above the graph indicates the position of each gene within the EV genome.
See this image and copyright information in PMC

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