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. 2013 Sep 30;8(9):e76434.
doi: 10.1371/journal.pone.0076434. eCollection 2013.

Prevalence and associated factors of glaucoma in rural central India. The Central India Eye and Medical Study

Vinay Nangia  1 , Jost B Jonas, Arshia Matin, Krishna Bhojwani, Ajit Sinha, Maithili Kulkarni, Rajesh Gupta, Anshu Khare, Shubhra Agarwal, Karishma Bhate, Prabhat Nangia, Purna Nangia, Songhomitra Panda-Jonas
Affiliations

Prevalence and associated factors of glaucoma in rural central India. The Central India Eye and Medical Study

Vinay Nangia et al. PLoS One. .

Abstract

Purpose: To assess the prevalence of glaucoma in rural Central India.

Methods: The population-based Central India Eye and Medical Study is a population-based study performed in a rural region of Central India. The study included 4711 subjects (aged 30+ years). A detailed ophthalmic and medical examination was performed. Glaucoma was defined by glaucomatous optic disc morphology, and in a second step, by the criteria of the International Society of Geographical and Epidemiological Ophthalmology (ISGEO).

Results: Optic disc photographs were available for 4570 (97.0%) subjects. Glaucoma was detected in 122 subjects (51 unilateral) (2.67% (95%CI: 2.20, 3.14). Glaucoma prevalence for the age groups of 30-39yrs, 40-49yrs, 50-59yrs, 60-69yrs, 70-79yrs, and 80+ years was 0.54% (95%CI: 0.11, 0.98), 1.03% (95%CI: 0.49, 1.57), 1.40% (95%CI: 0.58, 2.23), 6.62% (95%CI: 4.92, 8.31), 8.71% (95%CI: 5.55, 11.75), and 14.3% (95%CI: 4.13, 24.4), respectively. In multivariable analysis, glaucoma was associated with higher age (P<0.001), lower body mass index (P = 0.025), lower blood hemoglobin concentration (P = 0.03), higher intraocular pressure (P<0.001), disc hemorrhages (P<0.001), higher prevalence of myopic retinopathy (P<0.001), lower level of education (P = 0.03), longer axial length (P<0.001), thinner retinal nerve fiber layer (P<0.001), higher vertical cup/disc diameter ratio (P<0.001), and narrow anterior chamber angle (P = 0.02). Ratio of open-angle glaucoma to angle-closure glaucoma was 7.7:1 (1.93% (95%CI: 1.64, 2.22) to 0.24% (95%CI: 0.14, 0.34)). Using the ISGEO criteria, glaucoma prevalence was 2.8% (95%CI: 2.3, 3.3) with a less clear association with older age.

Conclusions: Glaucoma prevalence in remote rural Central India is comparable to other regions. Associated factors were older age, lower body mass index, lower blood concentration of hemoglobin, lower level of education, higher intraocular pressure, disc hemorrhage, myopic retinopathy, and longer axial length. The ratio of open-angle glaucoma to angle-closure glaucoma was about 8:1.

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Conflict of interest statement

Competing Interests: This work was supported by an unrestricted grant from Om Drishti Trust, Nagpur, India; Heidelberg Engineering Co., Heidelberg, Germany; Rotary Sight Saver Netherlands; ORBIS International; and Carl Zeiss Meditec Co., Jena, Germany. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Figures

Figure 1
Figure 1. Prevalence of Glaucoma (As defined by Ophthalmoscopy) in the Central India Eye and Medical Study.
Figure 2
Figure 2. Prevalence of Glaucoma (As Defined by the Criteria of the International Society of Geographical and Epidemiological Ophthalmology ISGEO) in the Central India Eye and Medical Study.
See this image and copyright information in PMC

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