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Review
. 2013 Nov;17(4):575-86, viii.
doi: 10.1016/j.cld.2013.07.001. Epub 2013 Sep 4.

Drug-induced acute liver failure

William M Lee  1
Affiliations
Review

Drug-induced acute liver failure

William M Lee. Clin Liver Dis. 2013 Nov.

Abstract

Although acute liver failure caused by drug-induced liver injury comprises a small fraction of overall drug-induced liver injury, these patients require high resource use and have relatively poor outcomes. Drug-induced liver injury caused by idiosyncrasy more often leads to death or transplantation than does acetaminophen acute liver failure, but the number of patients in each category receiving a graft is roughly the same. Efforts in the future to improve outcomes should focus on more effective treatments and better methods to identify those that might experience poor outcomes.

Keywords: Coagulopathy; Encephalopathy; Hepatocyte injury; Liver transplantation.

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Figures

Fig. 1
Fig. 1
Cause of acute liver failure in the United States.
Fig. 2
Fig. 2
Cox proportional hazards model by treatment and coma grade.
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