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Review
. 2014 Jun;69(1):113-24.
doi: 10.1016/j.yrtph.2013.09.008. Epub 2013 Oct 4.

Identifying important life stages for monitoring and assessing risks from exposures to environmental contaminants: results of a World Health Organization review

Elaine A Cohen Hubal  1 , Thea de Wet  2 , Lilo Du Toit  3 , Michael P Firestone  4 , Mathuros Ruchirawat  5 , Jacqueline van Engelen  6 , Carolyn Vickers  7
Affiliations
Review

Identifying important life stages for monitoring and assessing risks from exposures to environmental contaminants: results of a World Health Organization review

Elaine A Cohen Hubal et al. Regul Toxicol Pharmacol. 2014 Jun.

Abstract

In this paper, we summarize exposure-related issues to consider in determining the most appropriate age ranges and life stages for risk assessment. We then propose a harmonized set of age bins for monitoring and assessing risks from exposures to chemicals for global use. The focus is on preconception through adolescence, though the approach should be applicable to additional life stages. A two-tiered set of early life age groups is recommended. The first tier involves the adoption of guidance similar to the childhood age groups recommended by the U.S. Environmental Protection Agency, whereas the second tier consolidates some of those age groups to reduce the burden of developing age-specific exposure factors for different regions. While there is no single "correct" means of choosing a common set of age groups to use internationally in assessing early life exposure and risk, use of a set of defined age groups is recommended to facilitate comparisons of potential exposures and risks around the globe, the collection of data and analyses of aggregate exposure and cumulative risk. Application of these age groups for robust assessment of exposure and risk for specific populations will require region-specific exposure factors as well as local environmental monitoring data.

Keywords: Childhood life stages; Cultural and geographic modifying factors; Developmental changes in children; Exposure assessment; Exposure factors; Exposure to environmental contaminants; Harmonized early life age groups; Risk assessment; Windows of exposure; Windows of susceptibility.

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Figures

Fig. 1
Fig. 1
Mapping of integrated childhood life stages (NCS, 2011).
Fig. 2
Fig. 2
Framework of modifying factors for exposure associated with geography and culture.
See this image and copyright information in PMC

References

    1. Abubakar A., Holding P., Van Baar A., Newton C.R.J.C., Van de Vijver F.J.R. Monitoring psychomotor development in a resource limited setting: an evaluation of the Kilifi Developmental Inventory. Ann. Trop. Pediatr. 2008;28:217–226. - PMC - PubMed
    1. Adams J., Barone S., Jr., LaMantia A., Philen R., Rice D.C., Spear L., Susser E. Workshop to identify critical windows of exposure for children’s health: neurobehavioral work group summary. Environ. Health Perspect. 2000;108(Suppl. 3):535–544. - PMC - PubMed
    1. Aina O.F., Morakinyo O. Normative data on mental and motor development in Nigerian children. West Afr. J. Med. 2005;24(2):151–156. - PubMed
    1. Allen L.H. Malnutrition and human function: a comparison of conclusions from the INCAP and nutrition CRSP studies. Am. Inst. Nutr. 1995;125(4):1119–1126. - PubMed
    1. Armstrong T.W., Hushka L.J., Tell J.G., Zaleski R.T. A tiered approach for assessing children’s exposure. Environ. Health Perspect. 2000;108(6):469–474. - PMC - PubMed

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