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Review
. 2013 Oct;11(5):299-303.
doi: 10.1016/j.gpb.2013.08.003. Epub 2013 Oct 5.

Pluripotency of induced pluripotent stem cells

Chunjing Feng  1 , Yun-Dan Jia, Xiao-Yang Zhao
Affiliations
Review

Pluripotency of induced pluripotent stem cells

Chunjing Feng et al. Genomics Proteomics Bioinformatics. 2013 Oct.

Abstract

Induced pluripotent stem (iPS) cells can be generated by forced expression of four pluripotency factors in somatic cells. This has received much attention in recent years since it may offer us a promising donor cell source for cell transplantation therapy. There has been great progress in iPS cell research in the past few years. However, several issues need to be further addressed in the near future before the clinical application of iPS cells, like the immunogenicity of iPS cells, the variability of differentiation potential and most importantly tumor formation of the iPS derivative cells. Here, we review recent progress in research into the pluripotency of iPS cells.

Keywords: Cell transplantation therapy; Induced pluripotent stem cells; Pluripotency.

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Figures

Figure 1
Figure 1
Comparison of pluripotency levels of iPS cells from mouse, human and monkey
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See this image and copyright information in PMC

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