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Comment
. 2013 Oct;19(10):1207-8.
doi: 10.1038/nm.3355.

Therapeutically reeducating macrophages to treat GBM

Christopher Garris  1 , Mikael J Pittet
Affiliations
Comment

Therapeutically reeducating macrophages to treat GBM

Christopher Garris et al. Nat Med. 2013 Oct.

Abstract

Glioblastoma multiforme (GBM) is the most common type of aggressive malignant brain cancer. The current lack of successful therapeutics means that this disease has a dismal prognosis. However, a new study in mice offers hope for patients with GBM by demonstrating the efficacy of a novel drug that targets GBM-associated macrophages (pages 1264–1272).

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  • CSF-1R inhibition alters macrophage polarization and blocks glioma progression.
    Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, Olson OC, Quick ML, Huse JT, Teijeiro V, Setty M, Leslie CS, Oei Y, Pedraza A, Zhang J, Brennan CW, Sutton JC, Holland EC, Daniel D, Joyce JA. Pyonteck SM, et al. Nat Med. 2013 Oct;19(10):1264-72. doi: 10.1038/nm.3337. Epub 2013 Sep 22. Nat Med. 2013. PMID: 24056773 Free PMC article.

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