To B or not to B--that is the question for myocardial infarction
- PMID: 24100978
- DOI: 10.1038/nm.3367
To B or not to B--that is the question for myocardial infarction
Abstract
After myocardial infarction (MI), circulating B cells produce the chemokine Ccl7, which mobilizes inflammatory monocytes from the bone marrow into the blood, after which they are then recruited to the injured heart, a new study shows. B cell depletion after MI limits myocardial injury and improves heart function, suggesting a new approach for the management of acute MI (pages 1273–1280).
Comment on
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B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction.Nat Med. 2013 Oct;19(10):1273-80. doi: 10.1038/nm.3284. Epub 2013 Sep 15. Nat Med. 2013. PMID: 24037091 Free PMC article.
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