NKT cells: the smoking gun in fungal-induced asthma?
- PMID: 24100979
- DOI: 10.1038/nm.3360
NKT cells: the smoking gun in fungal-induced asthma?
Abstract
Aspergillus fumigatus is a fungus that is associated with a severe form of asthma, although the precise immunological basis for this disease is unclear. A new study in mice shows that natural killer T (NKT) cells are crucial for progression of A. fumigatus–induced asthma and also identifies a glycolipid antigen from this fungus that seems to drive this NKT cell–mediated inflammatory response (pages 1297–1304).
Comment on
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Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity.Nat Med. 2013 Oct;19(10):1297-304. doi: 10.1038/nm.3321. Epub 2013 Sep 1. Nat Med. 2013. PMID: 23995283 Free PMC article.
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