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. 2013 Nov 1;31(31):4026-7.
doi: 10.1200/JCO.2013.52.7747. Epub 2013 Oct 7.

Preservation of cognitive function in primary CNS lymphoma survivors a median of 12 years after enhanced chemotherapy delivery

Nancy D Doolittle  1 , Edit Dósa, Rongwei Fu, Leslie L Muldoon, Leeza M Maron, Meredith A Lubow, Rose Marie Tyson, Cynthia A Lacy, Dale F Kraemer, Robert W Butler, Edward A Neuwelt
Affiliations

Preservation of cognitive function in primary CNS lymphoma survivors a median of 12 years after enhanced chemotherapy delivery

Nancy D Doolittle et al. J Clin Oncol. .
No abstract available

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Figures

Fig 1.
Fig 1.
Baseline and long-term cognitive outcomes. Raw test scores were converted to z-scores that were based on normative values demographically adjusted to age. A domain score was obtained by averaging all test z-scores in each domain, for each participant. The z-score (mean ± SD) across survivors at baseline (pretreatment), long-term follow-up, and the change score are shown. The asterisks indicate statistical significance. There was improvement in Trail Making A, P = .0085; Trail Making B, P = .0411; and Attention/Executive Function domain, P < .001.
Fig A1.
Fig A1.
(A) The z-score (mean ± SD) across survivors at baseline (pretreatment), long-term follow-up, and the change score for Verbal Memory Learning, Verbal Memory Delayed, and for Verbal Memory Domain are shown. There was no significant change from baseline to long-term follow-up. (B) Number of patients who declined (z-score declined 1 SD or more), were stable (z-score remained within 1 SD of baseline score), and improved (z-score improved 1 SD or more) from baseline (pretreatment) to long-term follow-up for the following tests: Digit Span Forward, Digit Span Backward, Trail Making A, Trail Making B, Verbal Memory Learning, and Verbal Memory Delayed.
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References

    1. Neuwelt EA, Goldman DL, Dahlborg SA, et al. Primary CNS lymphoma treated with osmotic blood-brain barrier disruption: Prolonged survival and preservation of cognitive function. J Clin Oncol. 1991;9:1580–1590. - PubMed
    1. Angelov L, Doolittle ND, Kraemer DF, et al. Blood-brain barrier disruption and intra-arterial methotrexate-based therapy for newly diagnosed primary CNS lymphoma: A multi-institutional experience. J Clin Oncol. 2009;27:3503–3509. - PMC - PubMed
    1. Doolittle ND, Korfel A, Lubow MA, et al. Long-term cognitive function, neuroimaging, and quality of life in primary CNS lymphoma. Neurology. 2013;81:84–92. - PMC - PubMed
    1. Correa DD, Maron L, Harder H, et al. Cognitive functions in primary central nervous system lymphoma: Literature review and assessment guidelines. Ann Oncol. 2007;18:1145–1151. - PubMed
    1. Meyers CA, Brown PD. Role and relevance of neurocognitive assessment in clinical trials of patients with CNS tumors. J Clin Oncol. 2006;24:1305–1309. - PubMed

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