XPD Asp312Asn and Lys751Gln polymorphisms and breast cancer susceptibility: a meta-analysis

Abstract

The association between xeroderma pigmentosum complementation group D (XPD) Asp312Asn and Lys751Gln gene polymorphisms and breast cancer risk has been widely reported, but the results were inconsistent. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. A comprehensive search strategy was conducted towards the electronic databases including Medline, PubMed, Web of Science, Embase, and Chinese Biomedical Literature Database (Chinese). The association between the XPD polymorphism and breast cancer risk was conducted by odds ratios (ORs) and 95% confidence intervals (95% CIs). A total of 22 studies with 18,136 cases and 18,351 controls were included in our meta-analysis. Among these, 12 studies with 7,667 cases and 7,480 controls for Asp312Asn polymorphism and 20 studies with 10,469 cases and 10,871 controls for Lys751Gln polymorphism. With regard to Asp312Asn polymorphism, no significantly associated was found with breast cancer risk. However, significant association was found between Lys751Gln polymorphism and breast cancer risk under all genetic models in overall populations (C vs. A-OR = 1.10, 95% CI = 1.04-1.17, P = 0.002; CC vs. AA-OR = 1.17, 95% CI = 1.06-1.30, P = 0.003; AC vs. AA-OR = 1.06, 95% CI = 1.01-1.12, P = 0.032; CC vs. AC/AA-OR = 1.17, 95% CI = 1.04-1.32, P = 0.009; CC/AC vs. AA-OR = 1.07, 95% CI = 1.02-1.12, P = 0.005). In subgroup analysis base on ethnicity, significance was found in Caucasians and mix. The results suggest that XPD Asp312Asn polymorphism was not associated with breast cancer. The XPD Lys751Gln polymorphism significantly increased breast cancer risk, especially for Caucasian and mix.

Fig. 1

Flowchart of selection of studies for inclusion in the meta-analysis

Fig. 2

a The forest plot describing the meta-analysis under homozygous model for the association between XPD Asp312Asn polymorphism and the risk of breast cancer in overall population (AA vs. GG). b The forest plot describing the meta-analysis under homozygous model for the association between XPD Asp312Asn polymorphism and the risk of breast cancer in subgroup analysis base on ethnicity (AA vs. GG)

Fig. 3

a The forest plot describing the meta-analysis under homozygous model for the association between XPD Lys751Gln polymorphism and the risk of breast cancer in overall population (CC vs. AA). b The forest plot describing the meta-analysis under recessive model for the association between XPD Lys751Gln polymorphism and the risk of breast cancer in overall population (CC vs. CA/AA)

Fig. 4

a The forest plot describing the meta-analysis under heterozygote model for the association between XPD Lys751Gln polymorphism and the risk of breast cancer in subgroup analysis base on ethnicity (CA vs. AA). b The forest plot describing the meta-analysis under recessive model for the association between XPD Lys751Gln polymorphism and the risk of breast cancer in subgroup analysis base on ethnicity (CC vs. CA/AA)

Fig. 5

a Begg funnel plot for publication bias test for the association between XPD Asp312Asn polymorphism and the risk of breast cancer under homozygous model (AA vs. GG). Each point represents a separate study for the indicated association. Log [OR], natural logarithm of OR. Horizontal line means effect size. b Begg funnel plot for publication bias test for the association between XPD Lys751Gln polymorphism and the risk of breast cancer under heterozygote model (CA vs. AA). Each point represents a separate study for the indicated association. Log [OR], natural logarithm of OR. Horizontal line means effect size