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Review
. 2013 Sep;5 Suppl 4(Suppl 4):S446-8.
doi: 10.3978/j.issn.2072-1439.2013.07.36.

Neo-adjuvant chemotherapy in early stage non-small cell lung cancer

Ioannis Boukovinas  1 , Kosmas Tsakiridis, Paul Zarogoulidis, Nikolaos Machairiotis, Nikolaos Katsikogiannis, Ioanna Kougioumtzi, Kostantinos Zarogoulidis
Affiliations
Review

Neo-adjuvant chemotherapy in early stage non-small cell lung cancer

Ioannis Boukovinas et al. J Thorac Dis. 2013 Sep.

Abstract

Lung cancer treatment has evolved during the last decade from the non-specific cytotoxic drugs to targeted therapy. New diagnostic equipment such as the endobronchial ultrasound bronchoscopy and positron emission tomography has enhanced early lung cancer diagnosis. However; we still need additional novel biomarkers to assist the already used diagnostic techniques. Surgery is the still the best treatment for early lung cancer treatment. Several surgical techniques are being used based on the tumour location and cardiothoracic centre's experienced. There are however marginal situations where neo-adjuvant chemotherapy provides a "pre-step" for the patient. In the current work we will provide current data for the patients needing neo-adjuvant chemotherapy before proceeding to curative surgery.

Keywords: Lung cancer; early stage; neo-adjuvant.

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Figures

Figure 1
Figure 1
Schematic presentation of surgical treatment in non-small cell lung cancer.
See this image and copyright information in PMC

References

    1. Burdett S, Stewart LA, Rydzewska L. A systematic review and meta-analysis of the literature: chemotherapy and surgery versus surgery alone in non-small cell lung cancer. J Thorac Oncol 2006;1:611-21 - PubMed
    1. Depierre A, Milleron B, Moro-Sibilot D, et al. Preoperative chemotherapy followed by surgery compared with primary surgery in resectable stage I (except T1N0), II, and IIIa non-small-cell lung cancer. J Clin Oncol 2002;20:247-53 - PubMed
    1. Westeel V, Milleron BJ, Quoix EA, et al. Long-term results of the French randomized trial comparing neoadjuvant chemotherapy followed by surgery versus surgery alone in resectable non-small cell lung cancer. J Clin Oncol 2010;28:abstr 7003.
    1. Gilligan D, Nicolson M, Smith I, et al. Preoperative chemotherapy in patients with resectable non-small cell lung cancer: results of the MRC LU22/NVALT 2/EORTC 08012 multicentre randomised trial and update of systematic review. Lancet 2007;369:1929-37 - PubMed
    1. Pisters KM, Vallières E, Crowley JJ, et al. Surgery with or without preoperative paclitaxel and carboplatin in early-stage non-small-cell lung cancer: Southwest Oncology Group Trial S9900, an intergroup, randomized, phase III trial. J Clin Oncol 2010;28:1843-9 - PMC - PubMed