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. 2014 May;64(5):240-5.
doi: 10.1055/s-0033-1357127. Epub 2013 Oct 8.

Synthesis, antimicrobial evaluation and QSAR studies of 2-hydroxy propanoic acid derivatives

A Bansal  1 , P Kumar  1 , B Narasimhan  1
Affiliations

Synthesis, antimicrobial evaluation and QSAR studies of 2-hydroxy propanoic acid derivatives

A Bansal et al. Drug Res (Stuttg). 2014 May.

Abstract

A series of 2-hydroxypropanoic acid derivatives (1-26) was synthesized and characterized by physicochemical and spectral means. The synthesized compounds were evaluated for their in vitro antimicrobial potential and the results indicated that compounds 5 and 12 were found to be the most potent antimicrobial agents having pMICam values 1.67 and 1.64 µM/ml respectively. QSAR studies indicated the importance of topological parameter, Kier's valance second order molecular connectivity index (2χv) in describing the antimicrobial activities of synthesized 2-hydroxypropanoic acid derivatives.

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