A new PERKspective on neurodegeneration
- PMID: 24107775
- DOI: 10.1126/scitranslmed.3007641
A new PERKspective on neurodegeneration
Abstract
Targeting stress-induced kinases that regulate protein synthesis may be a new therapeutic strategy for treating neurodegenerative diseases.
Comment on
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Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.Nat Neurosci. 2013 Sep;16(9):1299-305. doi: 10.1038/nn.3486. Epub 2013 Aug 11. Nat Neurosci. 2013. PMID: 23933749 Free PMC article.
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Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice.Sci Transl Med. 2013 Oct 9;5(206):206ra138. doi: 10.1126/scitranslmed.3006767. Sci Transl Med. 2013. PMID: 24107777
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