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Comment
. 2014 Feb;95(2):137.
doi: 10.1038/clpt.2013.207. Epub 2013 Oct 9.

Response to "A case of 5-FU-related severe toxicity associated with the P.Y186C DPYD variant"

S M Offer  1 , R B Diasio  2
Affiliations
Comment

Response to "A case of 5-FU-related severe toxicity associated with the P.Y186C DPYD variant"

S M Offer et al. Clin Pharmacol Ther. 2014 Feb.
No abstract available

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Conflict of interest statement

Conflict of interest statement: The authors have no potential conflicts of interest to declare.

Figures

Figure 1
Figure 1
Enzyme activity was quantitated for wildtype DPD (WT), DPD harboring Y186C (Y186C), DPD containing both C29R and Y186C (C29R/Y186C), and a negative control mimic of DPYD*2A (*2A). Experiments were performed as three independent replicates, each presented as an “x.” Horizontal bars represent the mean of +/− SD of replicate experiments. P values were calculated using two-tailed Student t tests. The mean and SD of enzyme activity for C29R, as previously reported, are presented as the area between the dotted lines labeled “C29R.” Equivalent expression of DPD and variants was confirmed by western blotting (data not shown).
See this image and copyright information in PMC

Comment on

References

    1. Zaanan A, Dumont LM, Loriot MA, Taieb J, Narjoz C. A case of 5-FU related severe toxicity associated to the p.Y186C DPYD variant. Clin Pharmacol Ther. 2013 - PubMed
    1. Saif MW, Lee AM, Offer SM, McConnell K, Relias V, Diasio RB. A DPYD variant (Y186C) specific to individuals of African descent in a patient with life-threatening 5-FU toxicity potential for an individualized medicine approach. Mayo Clin Proc. 2013 Manuscript in Press. - PMC - PubMed
    1. Offer SM, Lee AM, Mattison LK, Fossum C, Wegner NJ, Diasio RB. A DPYD Variant (Y186C) in Individuals of African Ancestry Is Associated With Reduced DPD Enzyme Activity. Clin Pharmacol Ther. 2013;94(1):158–166. - PMC - PubMed
    1. Offer SM, Wegner NJ, Fossum C, Wang K, Diasio RB. Phenotypic profiling of DPYD variations relevant to 5-fluorouracil sensitivity using real-time cellular analysis and in vitro measurement of enzyme activity. Cancer Res. 2013;73(6):1958–1968. - PMC - PubMed
    1. Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, et al. Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing. Clin Pharmacol Ther. 2013 - PMC - PubMed

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