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Review
. 2013 Dec;15(6):590-9.
doi: 10.1007/s11906-013-0395-7.

Placental disease and the maternal syndrome of preeclampsia: missing links?

Dionne Tannetta  1 , Ian Sargent
Affiliations
Review

Placental disease and the maternal syndrome of preeclampsia: missing links?

Dionne Tannetta et al. Curr Hypertens Rep. 2013 Dec.

Abstract

Preeclampsia remains a significant obstetric risk worldwide. The pathophysiology of preeclampsia is complex, with multiple stages involving maladaptations in both placental and maternal physiology. The placenta links the pre-clinical stage of impaired remodeling of the uterine vasculature, occurring in early pregnancy, to the later clinical stages characterised by the maternal syndrome of hypertension and proteinuria. This review focuses on some of the recent candidates for the missing links in this process.

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Conflict of interest statement

Dionne Tannetta and Ian Sargent declare that they have no conflict of interest.

Figures

Fig 1
Fig 1
Schematic diagram illustrating the pathogenesis of preeclampsia and the possible involvement of factors recently implicated in disease progression. Dashed boxes and arrows denote the candidate factors and their source.
Fig 2
Fig 2
Proposed role of syncytiotrophoblast vesicles in the maternal syndrome of preeclampsia. ER = endoplasmic reticulum.
See this image and copyright information in PMC

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