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. 1985 Aug;82(16):5270-4.
doi: 10.1073/pnas.82.16.5270.

Assignment of the gene for human DNA polymerase alpha to the X chromosome

T S Wang, B E Pearson, H A Suomalainen, T Mohandas, L J Shapiro, J Schröder, D Korn

Assignment of the gene for human DNA polymerase alpha to the X chromosome

T S Wang et al. Proc Natl Acad Sci U S A. 1985 Aug.

Abstract

We have applied an assay based on a monoclonal antibody that discriminates the activity of human DNA polymerase alpha in rodent-human somatic cell hybrid clones to identify a single genetic locus that is both necessary and sufficient for the expression of DNA polymerase alpha. We have mapped this locus to the short arm of the human X chromosome, near the junction of bands Xp21.3 and Xp22.1, and demonstrated that it is not expressed from an inactive X chromosome.

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