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. 2013 Jul 24;69(Pt 8):o1297.
doi: 10.1107/S1600536813019788. eCollection 2013.

N-tert-But-oxy-carbonyl-α-(2-fluoro-benzyl)-l-proline

P Rajalakshmi  1 , N Srinivasan, R V Krishnakumar, Ibrahim Abdul Razak, Mohd Mustaqim Rosli
Affiliations

N-tert-But-oxy-carbonyl-α-(2-fluoro-benzyl)-l-proline

P Rajalakshmi et al. Acta Crystallogr Sect E Struct Rep Online. .

Abstract

In the title compound, C17H22FNO4, the pyrrolidine ring adopts an envelope conformation with the disordered com-ponents of the methylene C atom, with site occupancies of 0.896 (7) and 0.104 (7), being the flap on either side of the mean plane involving the other atoms of the ring. The carb-oxy-lic acid group forms dihedral angles of 72.06 (11) and 45.44 (5)° with the N-tert-but-oxy-carbonyl group and the 2-fluoro-benzyl group, respectively. In the crystal, two-dimensional layers of mol-ecules parallel to (001) are built through an R 4 (4)(23) motif generated via O-H⋯O, C-H⋯O and C-H⋯F inter-actions, and an R 2 (2)(11) motif generated by C-H⋯O and C-H⋯F inter-actions.

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Figures

Fig. 1.
Fig. 1.
Molecular structure of the title compound showing the major component of the disorder. Displacement ellipsoids for non-H atoms are drawn at the 50% probability level.
Fig. 2.
Fig. 2.
Part of the crystal structure of the title compound, showing R22(11) and R44(23) motifs through a combination of O—H···O, C—H···O and C—H···F hydrogen bonds and the formation of a two dimensional layer parallel to the ab plane. For the sake of clarity, H atoms not involved in hydrogen bonding have been omitted.
See this image and copyright information in PMC

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