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Review
. 2014 Jan:30:38-42.
doi: 10.1016/j.yebeh.2013.09.005. Epub 2013 Oct 7.

Magnetoencephalography in the study of epilepsy and consciousness

Elaine Foley  1 , Antonella Cerquiglini, Andrea Cavanna, Mable Angela Nakubulwa, Paul Lawrence Furlong, Caroline Witton, Stefano Seri
Affiliations
Free article
Review

Magnetoencephalography in the study of epilepsy and consciousness

Elaine Foley et al. Epilepsy Behav. 2014 Jan.
Free article

Abstract

The neural bases of altered consciousness in patients with epilepsy during seizures and at rest have raised significant interest in the last decade. This exponential growth has been supported by the parallel development of techniques and methods to investigate brain function noninvasively with unprecedented spatial and temporal resolution. In this article, we review the contribution of magnetoencephalography to deconvolve the bioelectrical changes associated with impaired consciousness during seizures. We use data collected from a patient with refractory absence seizures to discuss how spike-wave discharges are associated with perturbations in optimal connectivity within and between brain regions and discuss indirect evidence to suggest that this phenomenon might explain the cognitive deficits experienced during prolonged 3/s spike-wave discharges.

Keywords: Absence seizures; Connectivity; Epilepsy; Magnetoencephalography; Phase lag index.

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