MRI-diagnosed nonalcoholic fatty liver disease is correlated to insulin resistance in adolescents

Abstract

Rationale and objectives: To evaluate the presence of nonalcoholic fatty liver disease (NAFLD) in eutrophic and obese adolescents with magnetic resonance imaging (MRI) and its relationship to insulin resistance and other potential biomarkers.

Materials and methods: A total of 50 adolescents (aged 11-17 years), including 24 obese and 26 eutrophic adolescents, were evaluated using MRI exams for NAFLD diagnosis. Blood analysis was performed to measure glucose, insulin, total cholesterol, high-density lipoprotein cholesterol, triglycerides, fibrinogen, aminotransferases, alkaline phosphatase, gamma-gt, and C-reactive protein. The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index was also calculated. Laboratory test results and anthropometric assessment were statistically analyzed to determine potential correlation with NAFLD prevalence.

Results: The prevalence of NAFLD among the obese was significantly higher (83.3%; CI 95: 64.5-94.5%) than that of the eutrophic group (19.2%; CI 95: 7.4-37.6%). In multivariate analysis, only HOMA-IR was an independent risk factor for diagnosis NAFLD using MRI. Compared to eutrophic adolescents, the obese adolescents had significantly higher levels for all parameters measured except for total and high-density lipoprotein cholesterol, which were significantly lower.

Conclusion: The prevalence of NAFLD was 19.2% among eutrophic patients and 83.3% among obese patients. Only HOMA-IR was determined to be an independent risk factor for NAFLD.

Keywords: Adolescent; blood analysis; magnetic resonance imaging; nonalcoholic fatty liver disease; obese.