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Comment
. 2013 Oct 10;52(1):4-7.
doi: 10.1016/j.molcel.2013.09.023.

Same same but different: new structural insight into CRISPR-Cas complexes

Nadja Heidrich  1 , Jörg Vogel
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Same same but different: new structural insight into CRISPR-Cas complexes

Nadja Heidrich et al. Mol Cell. .
Free article

Abstract

Three papers in this issue of Molecular Cell report on the structure and functional activity of type III CRISPR-Cas effector complexes, revealing novel and conserved features of the ribonucleoprotein particles that underlie prokaryotic genome defense. The new structures suggest that type I and type III complexes follow the same architectural principles and are most likely descendants of a common ancestor, the differences in RNA and protein sequences and structure of individual components notwithstanding.

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