Same same but different: new structural insight into CRISPR-Cas complexes
- PMID: 24119398
- DOI: 10.1016/j.molcel.2013.09.023
Same same but different: new structural insight into CRISPR-Cas complexes
Abstract
Three papers in this issue of Molecular Cell report on the structure and functional activity of type III CRISPR-Cas effector complexes, revealing novel and conserved features of the ribonucleoprotein particles that underlie prokaryotic genome defense. The new structures suggest that type I and type III complexes follow the same architectural principles and are most likely descendants of a common ancestor, the differences in RNA and protein sequences and structure of individual components notwithstanding.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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Structure of the CRISPR interference complex CSM reveals key similarities with cascade.Mol Cell. 2013 Oct 10;52(1):124-34. doi: 10.1016/j.molcel.2013.08.020. Mol Cell. 2013. PMID: 24119402 Free PMC article.
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Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus.Mol Cell. 2013 Oct 10;52(1):135-145. doi: 10.1016/j.molcel.2013.09.013. Mol Cell. 2013. PMID: 24119403 Free PMC article.
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Structure of an RNA silencing complex of the CRISPR-Cas immune system.Mol Cell. 2013 Oct 10;52(1):146-52. doi: 10.1016/j.molcel.2013.09.008. Mol Cell. 2013. PMID: 24119404 Free PMC article.
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