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Randomized Controlled Trial
. 2013 Nov;116(5):584-90.
doi: 10.1016/j.oooo.2013.07.023.

Efficacy of intralesional betamethasone for erosive oral lichen planus and evaluation of recurrence: a randomized, controlled trial

Chuanxia Liu  1 , Bing Xie, Yi Yang, Duanxian Lin, Caixia Wang, Mei Lin, Lin Ge, Hongmei Zhou
Affiliations
Randomized Controlled Trial

Efficacy of intralesional betamethasone for erosive oral lichen planus and evaluation of recurrence: a randomized, controlled trial

Chuanxia Liu et al. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Nov.

Erratum in

  • Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 May;117(5):655

Abstract

Objective: This study aimed to determine the efficacy and safety of intralesional betamethasone in erosive oral lichen planus and to evaluate relapse of erosion.

Study design: Patients were randomly assigned to the experimental group (1.4 mg intralesional betamethasone) or to the control group (8 mg intralesional triamcinolone acetonide), and they received injections once a week for 2 weeks. Erosive area and pain level were assessed on days 1, 7 ± 2, and 14 ± 2. If the lesion disappeared, any recurrence within the following 3 months was recorded.

Results: Twenty-nine participants in the experimental group and 30 in the control group completed the protocol. Healed percentage was higher with betamethasone (93.1%) than with triamcinolone (66.7%; P = .02), and final reduction in erosion area was greater in the experimental group (21.276 ± 21.064 mm(2)) than in the control group (11.5 ± 12.95 mm(2); P = .02). Reduction in pain level did not differ between groups. The proportion of participants with recurrent erosions was significantly lower in the experimental group (14.8%) than in the control group (45%; P = .04).

Conclusions: Intralesional betamethasone may be used in the topical treatment of erosive oral lichen planus.

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