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Comment
. 2013 Oct 8;21(10):1722-3.
doi: 10.1016/j.str.2013.09.010.

Amyloid structures from Alzheimer's disease patients

Chad M Rienstra  1
Affiliations
Comment

Amyloid structures from Alzheimer's disease patients

Chad M Rienstra. Structure. .

Abstract

Lu and colleagues report the structures of β-amyloid fibrils seeded from the brain extracts of two Alzheimer’s disease patients, a game-changing study that could open new avenues for structure-based design of diagnostic imaging agents and aggregation inhibiting drugs.

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Figures

Figure 1
Figure 1
High-Resolution Structure of Ab40 Fibrils Seeded from Alzheimer’s Patient Tissue. (A) Three-fold symmetry repeat unit illustrating backbone (grey) and sidechain (green) atoms. (B) View of the idealized structure along the fibril axis. Adopted from Figure 5 of Lu et al. (2013) Cell 154, 1257–1268, with permission from Elsevier.
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