Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2014 May;30(5):959-62.
doi: 10.1007/s00381-013-2296-0.

Hypertrophic olivary degeneration with gadolinium enhancement after posterior fossa surgery in a child with medulloblastoma

Case Reports

Hypertrophic olivary degeneration with gadolinium enhancement after posterior fossa surgery in a child with medulloblastoma

Johannes Nowak et al. Childs Nerv Syst. 2014 May.

Abstract

Hypertrophic olivary degeneration (HOD) is a rare transsynaptic form of degeneration occurring secondary to the disruption of the dentato-rubro-olivary pathway ("Guillain-Mollaret triangle"). HOD can be caused by ischemic, hemorrhagic, traumatic, or neoplastic lesions, and it can also occur following posterior fossa surgery. MRI characteristics of HOD include T2 signal increase and hypertrophy. To date, blood–brain barrier disruption has not been reported in HOD. Here, we present the first case of HOD with temporary gadolinium enhancement in a 10-year-old child 7 months after resection of a posterior fossa medulloblastoma. The recognition of gadolinium enhancement as a radiological feature of HOD may help to distinguish between this benign secondary condition and tumor recurrence.

PubMed Disclaimer

References

    1. Radiology. 1994 Aug;192(2):539-43 - PubMed
    1. Cerebellum. 2013 Aug;12(4):469-74 - PubMed
    1. Arch Neurol. 2003 Dec;60(12):1796-800 - PubMed
    1. Neuroradiology. 1993;35(5):335-8 - PubMed
    1. Neurology. 1991 Apr;41(4):557-62 - PubMed

Publication types

LinkOut - more resources