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Review
. 2013 Dec;15(12):425.
doi: 10.1007/s11886-013-0425-8.

Cerebral microbleeds and macrobleeds: should they influence our recommendations for antithrombotic therapies?

Kellen E Haley  1 , Steven M Greenberg, M Edip Gurol  2
Affiliations
Review

Cerebral microbleeds and macrobleeds: should they influence our recommendations for antithrombotic therapies?

Kellen E Haley et al. Curr Cardiol Rep. 2013 Dec.

Abstract

Intracerebral hemorrhage (ICH, or macrobleeds) and cerebral microbleeds-smaller foci of hemosiderin deposits commonly detected by magnetic resonance imaging of older adults with or without ICH-are both associated with an increased risk of future ICH. These hemorrhagic pathologies also share risk factors with ischemic thromboembolic conditions that may require antithrombotic therapy, requiring specialists in cardiology, internal medicine, and neurology to weigh the benefits vs hemorrhagic risks of antithrombotics in individual patients. This paper will review recent advances in our understanding of hemorrhage prone cerebrovascular pathologies with a particular emphasis on use of these markers in decision making for antithrombotic use.

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Conflict of interest statement

Conflict of Interest

Kellen E. Haley, Steven M. Greenberg, and M. Edip Gurol declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Hemorrhagic findings of 2 patients with pathologically proven cerebral amyloid angiopathy. A, Head CT showing acute lobar parenchymal macrobleed (arrow) and intraventricular hemorrhage (bent arrow). B, GRE MRI shows lobar microbleeds (arrowheads) and sulcal siderosis (pentagon).
See this image and copyright information in PMC

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