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Review
. 2013 Dec;31(12):2599-606.
doi: 10.1002/stem.1574.

Concise review: Sowing the seeds of a fruitful harvest: hematopoietic stem cell mobilization

Jonathan Hoggatt  1 , Jennifer M Speth, Louis M Pelus
Affiliations
Review

Concise review: Sowing the seeds of a fruitful harvest: hematopoietic stem cell mobilization

Jonathan Hoggatt et al. Stem Cells. 2013 Dec.

Abstract

Hematopoietic stem cell transplantation is the only curative option for a number of malignant and nonmalignant diseases. As the use of hematopoietic transplant has expanded, so too has the source of stem and progenitor cells. The predominate source of stem and progenitors today, particularly in settings of autologous transplantation, is mobilized peripheral blood. This review will highlight the historical advances which led to the widespread use of peripheral blood stem cells for transplantation, with a look toward future enhancements to mobilization strategies.

Keywords: AMD3100 (plerixafor); CXCR4; Granulocyte-colony stimulating factor; Hematopoietic stem cell; Mobilization; Stem cell niche.

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Figures

Figure 1
Figure 1
Timeline of major advances leading to the use of peripheral blood stem cells for hematopoietic transplantation.
Figure 2
Figure 2
The new branches of hematopoietic stem cell mobilization, showing alternative agents to G-CSF.
See this image and copyright information in PMC

References

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