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. 2013 Oct;3(10):1096-8.
doi: 10.1158/2159-8290.CD-13-0506.

Are short telomeres predictive of advanced cancer?

Jerry W Shay  1
Affiliations

Are short telomeres predictive of advanced cancer?

Jerry W Shay. Cancer Discov. 2013 Oct.

Abstract

The combination of variable telomere length in cancer cells and shorter telomere length in cancer-associated stromal cells strongly correlates with progression to prostate cancer metastasis and cancer death. The implication is that telomere length measurements have potential not only as prognostic indicators of prostate cancer outcomes but also as risk stratification enrichment biomarkers for individualized therapeutic interventions.

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Figures

Figure
Figure. Evidence for a stem cell population in the rat prostate (top, based on data from reference 8). Evidence for the role of localized proliferative inflammatory atrophy in the human prostate (bottom, based on data from reference 11)
See this image and copyright information in PMC

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