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Comment
. 2013 Dec;9(12):699-700.
doi: 10.1038/nrneph.2013.210. Epub 2013 Oct 15.

Lupus nephritis: Ancestry, genetic risk and health disparities

Andrew S Bomback  1 , Ali G Gharavi
Affiliations
Comment

Lupus nephritis: Ancestry, genetic risk and health disparities

Andrew S Bomback et al. Nat Rev Nephrol. 2013 Dec.

Abstract

The disease manifestations and outcomes in lupus nephritis are exceptionally heterogeneous. In particular, some ethnic populations are disproportionately affected by the most severe forms of the disease. A new study exploring NF-κB dysregulation and its associated genetic variants might help explain the link between ancestry and outcomes in lupus nephritis.

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Comment on

  • ABIN1 dysfunction as a genetic basis for lupus nephritis.
    Caster DJ, Korte EA, Nanda SK, McLeish KR, Oliver RK, G'sell RT, Sheehan RM, Freeman DW, Coventry SC, Kelly JA, Guthridge JM, James JA, Sivils KL, Alarcon-Riquelme ME, Scofield RH, Adrianto I, Gaffney PM, Stevens AM, Freedman BI, Langefeld CD, Tsao BP, Pons-Estel BA, Jacob CO, Kamen DL, Gilkeson GS, Brown EE, Alarcon GS, Edberg JC, Kimberly RP, Martin J, Merrill JT, Harley JB, Kaufman KM, Reveille JD, Anaya JM, Criswell LA, Vila LM, Petri M, Ramsey-Goldman R, Bae SC, Boackle SA, Vyse TJ, Niewold TB, Cohen P, Powell DW. Caster DJ, et al. J Am Soc Nephrol. 2013 Nov;24(11):1743-54. doi: 10.1681/ASN.2013020148. Epub 2013 Aug 22. J Am Soc Nephrol. 2013. PMID: 23970121 Free PMC article.

References

    1. Nephrol Dial Transplant. 2003 Oct;18(10):2039-46 - PubMed
    1. Arthritis Res Ther. 2010;12(5):R174 - PubMed
    1. J Am Soc Nephrol. 2013 Nov;24(11):1743-54 - PubMed
    1. J Exp Med. 2011 Jun 6;208(6):1215-28 - PubMed
    1. Cell. 2007 Jul 13;130(1):25-35 - PubMed

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